尼洛替尼是一种口服可用的具有抗肿瘤活性的 Bcr-Abl 酪氨酸激酶抑制剂,以盐酸一水合盐的形式存在,是一种小分子酪氨酸激酶抑制剂,被批准用于治疗伊马替尼耐药的慢性髓细胞性白血病,是一种选择性Bcr-Abl激酶抑制剂,其抑制Bcr-Abl酪氨酸激酶活性和Bcr-Abl表达细胞增殖的能力是伊马替尼的10-30倍。

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