点击化学指的是一类模块化、高选择性、条件温和、高产率的偶联反应，以实现功能分子的高效快速合成。2022年诺贝尔化学奖授予了生物正交反应和点击化学的开拓者，这两个理念均秉持“大道至简”，即用简单高效的方法来实现分子的复合功能。点击化学成功带领化学进入功能主义时代，推动了材料化学、化学生物学、药物化学和生物医学等领域的发展。
O-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)hydroxylamine
Propargyl-PeG3-amine
14-Azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate
tert-Butyl 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoate
2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid
Dbco-c6-nhs ester
1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
rel-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
DBCO-PEG4 amine
Exo-BCN-PEG2-Boc-amine
2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
rel-((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
rel-2,5-Dioxopyrrolidin-1-yl 1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate
Dibenzocyclooctyne-PEG4 maleimide
3-(4-(3,6,9,12-Tetraoxapentadec-14-yn-1-yloxy)phenyl)-6-methyl-1,2,4,5-tetrazine
Methyltetrazine-nhs ester
2-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)acetic acid
Dbco-sulfo-nhs ester
N-(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
2-(4-(1,2,4,5-Tetrazin-3-yl)phenyl)acetic acid
Adibo-NH-peg2-biotin
2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate
Dbco-peg4-dbco
32-Azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontanoic acid
tert-Butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
O-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)hydroxylamine
2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22-heptaoxapentacos-24-yn-1-oate
tert-Butyl 3,6,9,12,15,18,21-heptaoxatetracos-23-yn-1-ylcarbamate
1-Bromo-3,6,9,12,15,18,21,24,27-nonaoxatriacont-29-yne
