考比替尼是一种有效的具有选择性的 MEK 抑制剂，能够抑制MEK1的活性，IC50 值为 4.2 nM，与一种BRAF抑制剂VimuraveNB联合用于治疗黑色素瘤。
2-Bromopyridine
2,3,4-Trifluorobenzoic acid
1-Cbz-3-Hydroxyazetidine
3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid
Azetidin-3-ol hydrochloride
Benzyl 3-oxoazetidine-1-carboxylate
2-Fluoro-4-iodoaniline
tert-Butyl 3-oxoazetidine-1-carboxylate
tert-Butyl piperidine-1-carboxylate
tert-Butyl 3-hydroxy-3-(pyridin-2-yl)azetidine-1-carboxylate
(3S,5R,8aS)-3-Phenylhexahydro-2H-oxazolo[3,2-a]pyridine-5-carbonitrile
(S)-2-(3-Hydroxyazetidin-3-yl)piperidine-1-carboxylic acid tert-butyl ester
tert-Butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
tert-Butyl 2-(1-((benzyloxy)carbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
2,2,2-trifluoro-1-(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)ethan-1-one.HCl
2,2,2-Trifluoro-1-(3-hydroxy-3-(pyridin-2-yl)azetidin-1-yl)ethanone hydrochloride
3-(pyridin-2-yl)azetidin-3-ol.2HCl
Cobimetinib Fumarate(2:1)
tert-Butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate
TERT-BUTYL 3-HYDROXY-3-((S)-1-((S)-2-HYDROXY-1-PHENYLETHYL)PIPERIDIN-2-YL)AZETIDINE-1-CARBOXYLATE
