鲁拉西酮是多巴胺 D2 和 5-HT7 的拮抗剂,IC50 值分别为 1.68 和 0.495 nM,也是 5-HT1A 受体的部分激动剂,IC50 值为 6.75 nM,是一种非典型抗精神病药。自2010年以来,它已经被FDA批准用于精神分裂症的治疗,并且从2013年开始用于治疗患有双相I障碍的成年人的抑郁症发作。

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