含肽段连接子是一类包含特定序列短肽的连接子，这类酶可裂解连接子已广泛应用于抗体偶联药物（ADC）中。ADC的作用机制是借助抗体的靶向性被精准的输送到靶细胞，接着由内吞途径进入细胞内，由于细胞内的溶酶体存在高浓度的蛋白水解酶，从而为含肽链连接子提供了在细胞内选择性裂解的机会，最终可以实现有效载荷的控制性释放。
(S)-2-(2-(2-Aminoacetamido)acetamido)-N-(2-((4-(hydroxymethyl)phenyl)amino)-2-oxoethyl)-3-phenylpropanamide
1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3,6,9,12-tetraoxapentadecan-15-amide
Azido-peg4-val-cit-pab-oh
4-((14S,17S)-1-Azido-14-isopropyl-12,15-dioxo-17-(3-ureidopropyl)-3,6,9-trioxa-13,16-diazaoctadecan-18-amido)benzyl (4-nitrophenyl) carbonate
4-((S)-2-((S)-2-(3-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl) carbonate
BCN-PEG3-VC-PFP Ester
(S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanoic acid
(5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoyl)-L-valyl-L-arginine
Mal-amido-PEG2-Val-Cit-PAB-OH
